Responsible Professor:  K. Liadaki 

Lecturers: K. Liadaki, V. Skamnaki, Α.Μ. Psarra, Chr. Mitsos, D. Leonidas, G. Papadopoulos, St. Papoutsopoulou 


This course describes all stages of drug development, from discovery up to drug market. Specifically, the course focuses on the analysis of the basic principles that govern the action of drugs and the identification of new possible targets. At the same time, modern approaches are described based on which new drug molecules are designed using computational biology. Particular emphasis is given on the detailed analysis of both preclinical (i.e., pharmacological profile, administration route, drug interactions) and clinical trials (i.e., phases I, II, III) of drug development. Finally, the clinical applications of the rapidly growing branch of pharmacogenetics-pharmacogenomics, which aims at personalized treatment with drugs adapted to the genetic profile of each patient, are reported in detail.  
  
•Basic principles of drug action (K. Liadaki)
•Protein kinases as drug targets (V. Skamnaki)
•Metabolic regulatory molecules as drug targets (A.M. Psarra)
•Bioactive molecules (Ch.Mitsos)
•Design of new drugs (D. Leonidas)
•Virtual scanning in the process of rational drug design (G. Papadopoulos)
•Clinical applications of pharmacogenetics - pharmacogenomics (K. Liadaki)
-Τranscriptional factors as therapeutic targets (St. Papoutsopoulou)